Importance After menopause, estradiol (E2) is predominately an intracrine hormone
circulating in very low serum concentrations. Objective The objective of this work is to
examine determinants of E2 concentrations in women beyond age 70 years. Design and
Setting A cross-sectional, community-based study was conducted. Participants A total of
5325 women participated, with a mean age of 75.1 years (±4.2 years) and not using any sex
steroid, antiandrogen/estrogen, glucocorticoid, or antiglycemic therapy. Main Outcome …